PPIPT01454
Target Protein Information
| Protein_Name | Syntenin-1 |
|---|---|
| Protein_Sequence | MSLYPSLEDLKVDKVIQAQTAYSANPASQAFVLVDASAALPPDGNLYPKLYPELSQYMGLSLNEAEICESMPMVSGAPAQGQLVARPSSVNYMVAPVTGNDAGIRRAEIKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTVTMHKDSSGHVGFIFKSGKITSIVKDSSAARNGLLTDHHICEINGQNVIGLKDAQIADILSTAGTVVTITIMPTFIFEHIIKRMAPSIMKSLMDHTIPEV |
| Organism_Source | Mus musculus |
| Functional_Classification | Scaffold/adaptor protein (PDZ domain) |
| Cellular_Localization | Cytoplasm |
| Gene_Names | Sdcbp |
| UniProt_ID | O08992 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Ephrin B1 C-terminal hexapeptide NIpYpYKV |
|---|---|
| Peptide_Sequence | NIpYpYKV |
| Peptide_Length | 8 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H](N)CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 993.17 |
|---|---|
| Aliphatic_Index | 85.00000 |
| Aromaticity | 0.25000 |
| Average_Rotatable_Bonds | 3.25000 |
| Charge_at_pH_7 | 0.99599 |
| Isoelectric_point | 9.14560 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 13 |
| Number_of_Hydrogen_Bond_Donors | 11 |
| Topological_Polar_Surface_Area | 359.01000 |
| X_logP_energy | -0.59260 |
Interaction Information
| Affinity | KD=151 uM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | None |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | PEPTIDES THAT MODULATE THE INTERACTION OF B CLASS EPHRINS AND PDZ DOMAINS |
| Release_Year | 2002 |
| Patent_ID | US20020147306A1 |