PPIPT01460

Target Protein Information
Protein_Name RAC-alpha serine/threonine-protein kinase
Protein_Sequence MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Organism_Source Homo sapiens
Functional_Classification Serine/threonine kinase
Cellular_Localization Cytoplasm
Gene_Names AKT1
UniProt_ID P31749
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PTR 6180
Peptide_Sequence RPRXYXX
Peptide_Length 7
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)O
Chemical_Modification X4=Nva;X6=Dap;X7=Hol
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification myristoylation
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 761.84
Aliphatic_Index 0.00000
Aromaticity 0.14286
Average_Rotatable_Bonds 3.14286
Charge_at_pH_7 1.99713
Isoelectric_point 11.14762
Number_of_Hydrogen_Bond_Acceptors 11
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 373.16000
X_logP_energy -4.81766
Interaction Information
Affinity IC50=0.9 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title Cell permeable conjugates of peptides for inhibition of protein kinases
Release_Year 2007
Patent_ID US20070078092A1