PPIPT01468
Target Protein Information
| Protein_Name | Kallikrein-2 |
|---|---|
| Protein_Sequence | MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKNSQVWLGRHNLFEPEDTGQRVPVSHSFPHPLYNMSLLKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLGLPTQEPALGTTCYASGWGSIEPEEFLRPRSLQCVSLHLLSNDMCARAYSEKVTEFMLCAGLWTGGKDTCGGDSGGPLVCNGVLQGITSWGPEPCALPEKPAVYTKVVHYRKWIKDTIAANP |
| Organism_Source | Homo sapiens |
| Functional_Classification | Serine protease |
| Cellular_Localization | Extracellular |
| Gene_Names | KLK2 |
| UniProt_ID | P20151 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | ARFKVWWAAG (SEQ ID NO:56) |
|---|---|
| Peptide_Sequence | ARFKVWWAAG |
| Peptide_Length | 10 |
| Peptide_SMILES | CC(C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)O |
| Chemical_Modification | S1- substitution |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1191.40 |
|---|---|
| Aliphatic_Index | 59.00000 |
| Aromaticity | 0.30000 |
| Average_Rotatable_Bonds | 3.40000 |
| Charge_at_pH_7 | 1.99769 |
| Isoelectric_point | 11.65178 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 13 |
| Number_of_Hydrogen_Bond_Donors | 17 |
| Topological_Polar_Surface_Area | 444.72000 |
| X_logP_energy | -0.80843 |
Interaction Information
| Affinity | IC50=2.2 uM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | NOVEL PEPTIDES |
| Release_Year | 2009 |
| Patent_ID | US20090214427A1 |