PPIPT01483

Target Protein Information
Protein_Name Programmed cell death 1 ligand 1
Protein_Sequence MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
Organism_Source Homo sapiens
Functional_Classification Immune checkpoint ligand
Cellular_Localization Plasma membrane
Gene_Names CD274
UniProt_ID Q9NZQ7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name BH2_mt
Peptide_Sequence HVVWHRESPSGQTDTKAA
Peptide_Length 18
Peptide_SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2006.17
Aliphatic_Index 43.33333
Aromaticity 0.05556
Average_Rotatable_Bonds 3.44444
Charge_at_pH_7 0.18173
Isoelectric_point 7.71345
Number_of_Hydrogen_Bond_Acceptors 30
Number_of_Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 908.91000
X_logP_energy -11.47163
Interaction Information
Affinity KD=119 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID 5IUS
Type Antagonist
Structure
Reference Information
Document_Type Patent
Title PEPTIDE - NANOPARTICLE CONJUGATES
Release_Year 2021
Patent_ID US20210187120A1