PPIPT01576
Target Protein Information
| Protein_Name | G1/S-specific cyclin-D1 |
|---|---|
| Protein_Sequence | MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI |
| Organism_Source | Homo sapiens |
| Functional_Classification | Cyclin |
| Cellular_Localization | Cytoplasm |
| Gene_Names | CCND1 |
| UniProt_ID | P24385 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | NA |
|---|---|
| Peptide_Sequence | MELLLWNKLKWNLAA |
| Peptide_Length | 15 |
| Peptide_SMILES | CSCC[C@H](N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1843.26 |
|---|---|
| Aliphatic_Index | 143.33333 |
| Aromaticity | 0.13333 |
| Average_Rotatable_Bonds | 4.06667 |
| Charge_at_pH_7 | 0.99917 |
| Isoelectric_point | 9.53730 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 22 |
| Number_of_Hydrogen_Bond_Donors | 23 |
| Topological_Polar_Surface_Area | 677.82000 |
| X_logP_energy | -0.46950 |
Interaction Information
| Affinity | IC50=3.68 nM |
|---|---|
| Affinity_Assay | radioligand binding assay |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | HLA-DRBINDING PEPTIDES AND THEIR USES |
| Release_Year | 2014 |
| Patent_ID | US20140377340A1 |