PPIPT01623

Target Protein Information
Protein_Name Immunoglobulin heavy constant gamma 2A
Protein_Sequence KTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGLDLDDVCAEAQDGELDGLWTTITIFISLFLLSVCYSASVTLFKVKWIFSSVVELKQTISPDYRNMIGQGA
Organism_Source Mus musculus
Functional_Classification IgG heavy chain constant region
Cellular_Localization Extracellular
Gene_Names Ighg2a
UniProt_ID P01865
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name u-amyloid peptide 1-12
Peptide_Sequence DAEFRHDSGYEV
Peptide_Length 12
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification biotin
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1424.45
Aliphatic_Index 32.50000
Aromaticity 0.16667
Average_Rotatable_Bonds 3.75000
Charge_at_pH_7 -2.90752
Isoelectric_point 4.10374
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 663.66000
X_logP_energy -6.87023
Interaction Information
Affinity KD=36.1 pM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title Antibodies against amyloid-beta peptide
Release_Year 2010
Patent_ID EP2177536A1