PPIPT01706
Target Protein Information
| Protein_Name | Hepatitis A virus cellular receptor 2 |
|---|---|
| Protein_Sequence | MFSHLPFDCVLLLLLLLLTRSSEVEYRAEVGQNAYLPCFYTPAAPGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWTSRYWLNGDFRKGDVSLTIENVTLADSGIYCCRIQIPGIMNDEKFNLKLVIKPAKVTPAPTRQRDFTAAFPRMLTTRGHGPAETQTLGSLPDINLTQISTLANELRDSRLANDLRDSGATIRIGIYIGAGICAGLALALIFGALIFKWYSHSKEKIQNLSLISLANLPPSGLANAVAEGIRSEENIYTIEENVYEVEEPNEYYCYVSSRQQPSQPLGCRFAMP |
| Organism_Source | Homo sapiens |
| Functional_Classification | Virus entry receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | HAVCR2 |
| UniProt_ID | Q8TDQ0 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | P1307 |
|---|---|
| Peptide_Sequence | SHDTRSPFTWGR |
| Peptide_Length | 12 |
| Peptide_SMILES | C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1446.54 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.16667 |
| Average_Rotatable_Bonds | 3.50000 |
| Charge_at_pH_7 | 1.08933 |
| Isoelectric_point | 10.39953 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 21 |
| Number_of_Hydrogen_Bond_Donors | 25 |
| Topological_Polar_Surface_Area | 661.12000 |
| X_logP_energy | -8.45136 |
Interaction Information
| Affinity | KD=117 uM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | IMMUNE CHECKPOINT TIM3-TARGETING BINDING PEPTIDE AND APPLICATION THEREOF |
| Release_Year | 2022 |
| Patent_ID | EP4105227A1 |