PPIPT01743

Target Protein Information
Protein_Name Erythropoietin receptor
Protein_Sequence MDKLRVPLWPRVGPLCLLLAGAAWAPSPSLPDPKFESKAALLASRGSEELLCFTQRLEDLVCFWEEAASSGMDFNYSFSYQLEGESRKSCSLHQAPTVRGSVRFWCSLPTADTSSFVPLELQVTEASGSPRYHRIIHINEVVLLDAPAGLLARRAEEGSHVVLRWLPPPGAPMTTHIRYEVDVSAGNRAGGTQRVEVLEGRTECVLSNLRGGTRYTFAVRARMAEPSFSGFWSAWSEPASLLTASDLDPLILTLSLILVLISLLLTVLALLSHRRTLQQKIWPGIPSPESEFEGLFTTHKGNFQLWLLQRDGCLWWSPGSSFPEDPPAHLEVLSEPRWAVTQAGDPGADDEGPLLEPVGSEHAQDTYLVLDKWLLPRTPCSENLSGPGGSVDPVTMDEASETSSCPSDLASKPRPEGTSPSSFEYTILDPSSQLLCPRALPPELPPTPPHLKYLYLVVSDSGISTDYSSGGSQGVHGDSSDGPYSHPYENSLVPDSEPLHPGYVACS
Organism_Source Mus musculus
Functional_Classification Class I cytokine receptor
Cellular_Localization Plasma membrane
Gene_Names Epor
UniProt_ID P14753
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ML4-1
Peptide_Sequence KKAVSGLKTLTHILRALGAQKEAI
Peptide_Length 24
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2547.08
Aliphatic_Index 126.25000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.79167
Charge_at_pH_7 4.08949
Isoelectric_point 11.24820
Number_of_Hydrogen_Bond_Acceptors 36
Number_of_Hydrogen_Bond_Donors 38
Topological_Polar_Surface_Area 1068.36000
X_logP_energy -9.54703
Interaction Information
Affinity KD=4.31 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID 1EER
Type Agonist
Structure
Reference Information
Document_Type Patent
Title USE OF ERYTHROPOIETIN-DERIVED PEPTIDE THROUGH EFFECT ON CELL DAMAGE PREVENTION THEREOF
Release_Year 2019
Patent_ID US20190375810A1