PPIPT01754
Target Protein Information
| Protein_Name | Interleukin 31 |
|---|---|
| Protein_Sequence | MLSHTGPSRFALFLLCSMETLLSSHMAPTHQLPPSDVRKIILELQPLSRGLLEDYQKKETGVPESNRTLLLCLTSDSQPPRLNSSAILPYFRAIRPLSDKNIIDKIIEQLDKLKFQHEPETEISVPADTFECKSFILTILQQFSACLESVFKSLNSGPQ |
| Organism_Source | Canis lupus familiaris |
| Functional_Classification | Interleukin 3 |
| Cellular_Localization | Extracellular |
| Gene_Names | IL31 |
| UniProt_ID | A0A8C0PEY7 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | ZTS-561 |
|---|---|
| Peptide_Sequence | NTEISVPADTFERKSFC |
| Peptide_Length | 17 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(N)=O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | Side chain-side chain cyclization; C1<->C16; disulfide bond |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1944.15 |
|---|---|
| Aliphatic_Index | 45.88235 |
| Aromaticity | 0.11765 |
| Average_Rotatable_Bonds | 3.64706 |
| Charge_at_pH_7 | -1.06029 |
| Isoelectric_point | 4.42636 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 29 |
| Number_of_Hydrogen_Bond_Donors | 30 |
| Topological_Polar_Surface_Area | 843.96000 |
| X_logP_energy | -9.98333 |
Interaction Information
| Affinity | KD=1.02 nM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | PEPTIDE VACCINES AGAINST INTERLEUKIN-31 |
| Release_Year | 2019 |
| Patent_ID | US20190282704A1 |