PPIPT01756

Target Protein Information
Protein_Name Interleukin 31
Protein_Sequence MLSHAGPARFALFLLCCMETLLPSHMAPAHRLQPSDVRKIILELRPMSKGLLQDYVSKEIGLPESNHSSLPCLSSDSQLPHINGSAILPYFRAIRPLSDKNTIDKIIEQLDKLKFQREPEAKVSMPADNFERKNFILAVLQQFSACLEHVLQSLNSGPQ
Organism_Source Felis catus
Functional_Classification Interleukin 3
Cellular_Localization Extracellular
Gene_Names IL31
UniProt_ID A0A2I2UKP7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ZTS-563
Peptide_Sequence CAKVSMPADNFERKNFILTC
Peptide_Length 20
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C1<->C20; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2287.70
Aliphatic_Index 63.50000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.75000
Charge_at_pH_7 0.87566
Isoelectric_point 8.22799
Number_of_Hydrogen_Bond_Acceptors 33
Number_of_Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 922.61000
X_logP_energy -9.01353
Interaction Information
Affinity KD=1.48 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title PEPTIDE VACCINES AGAINST INTERLEUKIN-31
Release_Year 2019
Patent_ID US20190282704A1