PPIPT01759

Target Protein Information
Protein_Name Kininogen-1
Protein_Sequence MKLITILFLCSRLLLSLTQESQSEEIDCNDKDLFKAVDAALKKYNSQNQSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVQSGKTWQDCEYKDAAKAATGECTATVGKRSSTKFSVATQTCQITPAEGPVVTAQYDCLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKENFLFLTPDCKSLWNGDTGECTDNAYIDIQLRIASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEETLTHTITKLNAENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKLGQSLDCNAEVYVVPWEKKIYPTVNCQPLGMISLMKRPPGFSPFRSSRIGEIKEETTVSPPHTSMAPAQDEERDSGKEQGHTRRHDWGHEKQRKHNLGHGHKHERDQGHGHQRGHGLGHGHEQQHGLGHGHKFKLDDDLEHQGGHVLDHGHKHKHGHGHGKHKNKGKKNGKHNGWKTEHLASSSEDSTTPSAQTQEKTEGPTPIPSLAKPGVTVTFSDFQDSDLIATMMPPISPAPIQSDDDWIPDIQIDPNGLSFNPISDFPDTTSPKCPGRPWKSVSEINPTTQMKESYYFDLTDGLS
Organism_Source Homo sapiens
Functional_Classification Kinin precursor
Cellular_Localization Extracellular
Gene_Names KNG1
UniProt_ID P01042
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Bradykinin
Peptide_Sequence RPPGFSPFRK
Peptide_Length 10
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Lys-biotin
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1188.40
Aliphatic_Index 0.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 3.30000
Charge_at_pH_7 2.99768
Isoelectric_point 12.51648
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 468.90000
X_logP_energy -3.95526
Interaction Information
Affinity KD=45 nM
Affinity_Assay binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title METHODS AND COMPOSITIONS FOR PROTEIN AND PEPTIDE SEQUENCING
Release_Year 2021
Patent_ID US20210102248A1