PPIPT01760
Target Protein Information
| Protein_Name | Vasopressin-neurophysin 2-copeptin |
|---|---|
| Protein_Sequence | MPDTMLPACFLGLLAFSSACYFQNCPRGGKRAMSDLELRQCLPCGPGGKGRCFGPSICCADELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAAFGVCCNDESCVTEPECREGFHRRARASDRSNATQLDGPAGALLLRLVQLAGAPEPFEPAQPDAY |
| Organism_Source | Homo sapiens |
| Functional_Classification | Hormone precursor (vasopressin-neurophysin) |
| Cellular_Localization | Extracellular |
| Gene_Names | AVP |
| UniProt_ID | P01185 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Argipressin |
|---|---|
| Peptide_Sequence | CYFQNCPRGK |
| Peptide_Length | 10 |
| Peptide_SMILES | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | Side chain-side chain cyclization; C1<->C6; disulfide bond |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Lys-biotin |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 1215.41 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.20000 |
| Average_Rotatable_Bonds | 3.70000 |
| Charge_at_pH_7 | 1.87289 |
| Isoelectric_point | 8.79809 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 18 |
| Number_of_Hydrogen_Bond_Donors | 19 |
| Topological_Polar_Surface_Area | 510.76000 |
| X_logP_energy | -5.51713 |
Interaction Information
| Affinity | KD=45 nM |
|---|---|
| Affinity_Assay | binding assay |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | METHODS AND COMPOSITIONS FOR PROTEIN AND PEPTIDE SEQUENCING |
| Release_Year | 2021 |
| Patent_ID | US20210102248A1 |