PPIPT01792

Target Protein Information
Protein_Name Pro-neuropeptide Y
Protein_Sequence MLGNKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMRESTENVPRTRLEDPAMW
Organism_Source Homo sapiens
Functional_Classification Neuropeptide precursor
Cellular_Localization Extracellular
Gene_Names NPY
UniProt_ID P01303
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name D-Trp-NPY
Peptide_Sequence YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQdRY
Peptide_Length 37
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC
Chemical_Modification d32=W (D-Trp at position 32)
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 4387.81
Aliphatic_Index 52.97297
Aromaticity 0.13514
Average_Rotatable_Bonds 3.67568
Charge_at_pH_7 -0.91033
Isoelectric_point 5.66534
Number_of_Hydrogen_Bond_Acceptors 62
Number_of_Hydrogen_Bond_Donors 65
Topological_Polar_Surface_Area 1892.97000
X_logP_energy -18.57612
Interaction Information
Affinity Ki=53 nM
Affinity_Assay radioligand binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title METHODS OF MODIFYING FEEDING BEHAVIOR閳
Release_Year 2006
Patent_ID US20060014242A1