PPIPT01814

Target Protein Information
Protein_Name Intercellular adhesion molecule 1
Protein_Sequence MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP
Organism_Source Homo sapiens
Functional_Classification Ig-superfamily adhesion molecule
Cellular_Localization Extracellular
Gene_Names ICAM1
UniProt_ID P05362
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name cLAB.2L
Peptide_Sequence XGVDVDQDGETC
Peptide_Length 12
Peptide_SMILES CC(C)[C@H](NC(=O)CNC(=O)CN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O)C(C)C
Chemical_Modification X1=Pen
Cyclization_Method Side chain cyclization; X1<->C12; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1194.19
Aliphatic_Index 48.33333
Aromaticity 0.00000
Average_Rotatable_Bonds 3.25000
Charge_at_pH_7 -4.06088
Isoelectric_point 3.26047
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 595.94000
X_logP_energy -9.19770
Interaction Information
Affinity KD=56.5 uM
Affinity_Assay Fluorescence Polarization
PDB_ID 1IC1
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title LEUKOCYTE INTERNALIZED PEPTIDE-DRUG CONJUGATES
Release_Year 2004
Patent_ID US20040037775A1