PPIPT01876
Target Protein Information
| Protein_Name | Melanoma-associated antigen 4 |
|---|---|
| Protein_Sequence | MSSEQKSQHCKPEEGVEAQEEALGLVGAQAPTTEEQEAAVSSSSPLVPGTLEEVPAAESAGPPQSPQGASALPTTISFTCWRQPNEGSSSQEEEGPSTSPDAESLFREALSNKVDELAHFLLRKYRAKELVTKAEMLERVIKNYKRCFPVIFGKASESLKMIFGIDVKEVDPASNTYTLVTCLGLSYDGLLGNNQIFPKTGLLIIVLGTIAMEGDSASEEEIWEELGVMGVYDGREHTVYGEPRKLLTQDWVQENYLEYRQVPGSNPARYEFLWGPRALAETSYVKVLEHVVRVNARVRIAYPSLREAALLEEEEGV |
| Organism_Source | Homo sapiens |
| Functional_Classification | Cancer/testis antigen |
| Cellular_Localization | Nucleus |
| Gene_Names | MAGEA4 |
| UniProt_ID | P43358 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | MAGEA4_B0702 |
|---|---|
| Peptide_Sequence | MPSLREAAL |
| Peptide_Length | 9 |
| Peptide_SMILES | CSCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 987.18 |
|---|---|
| Aliphatic_Index | 108.88889 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.44444 |
| Charge_at_pH_7 | -0.00024 |
| Isoelectric_point | 6.41015 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 14 |
| Number_of_Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 406.76000 |
| X_logP_energy | -3.21163 |
Interaction Information
| Affinity | IC50=47.48 nM |
|---|---|
| Affinity_Assay | ProImmune REVEAL assay |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | IMMUNOGENIC HETEROCLITIC PEPTIDES FROM CANCER - ASSOCIATED PROTEINS AND METHODS OF USE THEREOF |
| Release_Year | 2021 |
| Patent_ID | US20210177955A1 |