PPIPT01877
Target Protein Information
| Protein_Name | G antigen 1 |
|---|---|
| Protein_Sequence | MSWRGRSTYYWPRPRRYVQPPEMIGPMRPEQFSDEVEPATPEEGEPATQRQDPAAAQEGEDEGASAGQGPKPEADSQEQGHPQTGCECEDGPDGQEMDPPNPEEVKTPEEGEGQSQC |
| Organism_Source | Homo sapiens |
| Functional_Classification | Cell surface antigen |
| Cellular_Localization | Nucleus |
| Gene_Names | GAGE1 |
| UniProt_ID | P0DTW1 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | GAGE1_B0702 |
|---|---|
| Peptide_Sequence | WPRPRRYVM |
| Peptide_Length | 9 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1260.53 |
|---|---|
| Aliphatic_Index | 32.22222 |
| Aromaticity | 0.22222 |
| Average_Rotatable_Bonds | 3.88889 |
| Charge_at_pH_7 | 2.99712 |
| Isoelectric_point | 12.20421 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 15 |
| Number_of_Hydrogen_Bond_Donors | 19 |
| Topological_Polar_Surface_Area | 500.26000 |
| X_logP_energy | -1.83969 |
Interaction Information
| Affinity | IC50=2966 nM |
|---|---|
| Affinity_Assay | ProImmune REVEAL assay |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | IMMUNOGENIC HETEROCLITIC PEPTIDES FROM CANCER - ASSOCIATED PROTEINS AND METHODS OF USE THEREOF |
| Release_Year | 2021 |
| Patent_ID | US20210177955A1 |