PPIPT01883

Target Protein Information
Protein_Name Kinetochore protein Nuf2
Protein_Sequence METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIRLEHFYMMPVNSEVMYPHLMEGFLPFSNLVTHLDSFLPICRVNDFETADILCPKAKRTSRFLSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMST
Organism_Source Homo sapiens
Functional_Classification Kinetochore complex subunit
Cellular_Localization Nucleus
Gene_Names NUF2
UniProt_ID Q9BZD4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name NUF2_A0201
Peptide_Sequence YLMPVNSEV
Peptide_Length 9
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1051.22
Aliphatic_Index 107.77778
Aromaticity 0.11111
Average_Rotatable_Bonds 3.44444
Charge_at_pH_7 -1.00109
Isoelectric_point 3.84998
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 408.18000
X_logP_energy -2.42510
Interaction Information
Affinity IC50=9.4 nM
Affinity_Assay ProImmune REVEAL assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title IMMUNOGENIC HETEROCLITIC PEPTIDES FROM CANCER - ASSOCIATED PROTEINS AND METHODS OF USE THEREOF
Release_Year 2021
Patent_ID US20210177955A1