PPIPT01884

Target Protein Information
Protein_Name L-dopachrome tautomerase
Protein_Sequence MSPLWWGFLLSCLGCKILPGAQGQFPRVCMTVDSLVNKECCPRLGAESANVCGSQQGRGQCTEVRADTRPWSGPYILRNQDDRELWPRKFFHRTCKCTGNFAGYNCGDCKFGWTGPNCERKKPPVIRQNIHSLSPQEREQFLGALDLAKKRVHPDYVITTQHWLGLLGPNGTQPQFANCSVYDFFVWLHYYSVRDTLLGPGRPYRAIDFSHQGPAFVTWHRYHLLCLERDLQRLIGNESFALPYWNFATGRNECDVCTDQLFGAARPDDPTLISRNSRFSSWETVCDSLDDYNHLVTLCNGTYEGLLRRNQMGRNSMKLPTLKDIRDCLSLQKFDNPPFFQNSTFSFRNALEGFDKADGTLDSQVMSLHNLVHSFLNGTNALPHSAANDPIFVVLHSFTDAIFDEWMKRFNPPADAWPQELAPIGHNRMYNMVPFFPPVTNEELFLTSDQLGYSYAIDLPVSVEETPGWPTTLLVVMGTLVALVGLFVLLAFLQYRRLRKGYTPLMETHLSSKRYTEEA
Organism_Source Homo sapiens
Functional_Classification Tautomerase
Cellular_Localization Cytoplasm
Gene_Names DCT
UniProt_ID P40126
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name TRP-2223-237
Peptide_Sequence HLLCLERDLQRLIGN
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1793.12
Aliphatic_Index 156.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.13333
Charge_at_pH_7 0.02913
Isoelectric_point 7.36076
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 783.98000
X_logP_energy -6.00396
Interaction Information
Affinity IC50=7.5 uM
Affinity_Assay Competitive binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title Peptides useful for diagnosis and therapy of TRP-2+ and/or TRP-1+ tumors
Release_Year 2005
Patent_ID EP001555271A1