PPIPT01911
Target Protein Information
| Protein_Name | Metallothionein-2 |
|---|---|
| Protein_Sequence | MDPNCSCAAGDSCTCAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGASDKCSCCA |
| Organism_Source | Homo sapiens |
| Functional_Classification | Metal-binding protein |
| Cellular_Localization | Cytoplasm |
| Gene_Names | MT2A |
| UniProt_ID | P02795 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | MTAcc |
|---|---|
| Peptide_Sequence | AQGSICKGASDKSS |
| Peptide_Length | 14 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1338.46 |
|---|---|
| Aliphatic_Index | 42.14286 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.35714 |
| Charge_at_pH_7 | 0.93587 |
| Isoelectric_point | 8.54049 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 24 |
| Number_of_Hydrogen_Bond_Donors | 24 |
| Topological_Polar_Surface_Area | 654.97000 |
| X_logP_energy | -12.05340 |
Interaction Information
| Affinity | KD=89.5 nM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Allosteric modulator |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | METALLOTHIONEIN-DERIVED PEPTIDE FRAGMENTS |
| Release_Year | 2010 |
| Patent_ID | US20100166759A1 |