PPIPT01918
Target Protein Information
| Protein_Name | GTPase KRas |
|---|---|
| Protein_Sequence | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM |
| Organism_Source | Homo sapiens |
| Functional_Classification | Small GTPase (Ras family) |
| Cellular_Localization | Plasma membrane |
| Gene_Names | KRAS |
| UniProt_ID | P01116 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | 7b10 |
|---|---|
| Peptide_Sequence | XLRGDXX |
| Peptide_Length | 7 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)CN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)NCC(=O)O |
| Chemical_Modification | X1=L-propargylglycine; X6=guanidinophenylalanine; X7=L-azidolysine |
| Cyclization_Method | Side chain-side chain cyclization; X1<->X7; other bonds |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | PEG-Biotin |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 630.66 |
|---|---|
| Aliphatic_Index | 55.71429 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.00000 |
| Charge_at_pH_7 | -0.00157 |
| Isoelectric_point | 6.33872 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 10 |
| Number_of_Hydrogen_Bond_Donors | 12 |
| Topological_Polar_Surface_Area | 337.12000 |
| X_logP_energy | -5.38323 |
Interaction Information
| Affinity | EC50=17.5 uM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | CYCLIC PEPTIDE BINDER AGAINST ONCOGENIC K-RAS |
| Release_Year | 2018 |
| Patent_ID | US20180319844A1 |