PPIPT01925

Target Protein Information
Protein_Name RAC-alpha serine/threonine-protein kinase
Protein_Sequence MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Organism_Source Homo sapiens
Functional_Classification Serine/threonine kinase
Cellular_Localization Cytoplasm
Gene_Names AKT1
UniProt_ID P31749
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PTR 6260
Peptide_Sequence RPRXEXSF
Peptide_Length 8
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Chemical_Modification X4=Orn; X5=Glu(NH-(CH2)2-NH-SO2-isoquinoline)
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification cholesteryl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 904.98
Aliphatic_Index 0.00000
Aromaticity 0.12500
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 0.99975
Isoelectric_point 10.39777
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 439.56000
X_logP_energy -5.81276
Interaction Information
Affinity IC50=0.8 uM
Affinity_Assay radiometric in vitro kinase assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title CELL PERMEABLE CONJUGATES OF PEPTIDES FOR INHIBITION OF PROTEIN KINASES
Release_Year 2009
Patent_ID US20090156507A1