PPIPT01958

Target Protein Information
Protein_Name Sphingomyelinase
Protein_Sequence MLPENSDELPEKINILTLNCWGLKFLSTYRRERLLEIGKRIARSDDPPHIVGLQECWTQEDYSNIRRETREILPYGKFYFSGIFGGGLAILSKWPIEESTMYEYPLNGRPTAFFRGDWFVGKGVACARIRIGPSPTDTAEVFCTHLHAPYEKEPRDSYLCHRTAQAWEIGKLMRAAAERGHLVIGLGDFNMLPQSFAHRLITSHAPVKDVWIHLHPDSSIGAAVDAVEMARKKPVPSADFNIIENGATCDGIFNTWRWNKSQQKRLKREGHIEVDGQLPDPLGKRLDYIFIGDGAYSNFSSPRKWTIVSARVSMMERHPTLHCSLSDHFGVEATITLDVAKDDDSEEDLSSFLPIQKHIESIRSRSSACITTRITAENARDPNANPKSTASAAVAHQQQQVTRMAGMYDQILHMISAYTGRERFQRRARLGHFIVSLVITIACLVGVWWSPHAFVSFILCLVSSLSLVAGTIDGLIGGLFVSSELRALKEFEWEIRNARRTVLGLGLDIEEEHRSPKPVQRGWCP
Organism_Source Blastomyces gilchristii (strain SLH14081)
Functional_Classification Sphingomyelinase
Cellular_Localization Plasma membrane
Gene_Names None
UniProt_ID A0A179UJC7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name calnexin peptide #1
Peptide_Sequence LVVKNPAAHHAIS
Peptide_Length 13
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CC(C)C)C(C)C)C(C)C)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1356.59
Aliphatic_Index 127.69231
Aromaticity 0.00000
Average_Rotatable_Bonds 3.15385
Charge_at_pH_7 1.17951
Isoelectric_point 9.70398
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 550.43000
X_logP_energy -4.88570
Interaction Information
Affinity IC50=500 nM
Affinity_Assay in silico prediction (IEDB)
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title PEPTIDE MHCII TETRAMERS TO DETECT ENDOGENOUS CALNEXIN SPECIFIC CD4 T CELLS
Release_Year 2015
Patent_ID US20150301044A1