PPIPT01969

Target Protein Information
Protein_Name Hyccin
Protein_Sequence MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSELLEPVCHQLFEFYRSGEEQLLQFTLQFLPELIWCYLAVSASRNVHSSGCIEALLLGVYNLEIVDKQGHTKVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKVVYSGPHPQREMLTAQNRFEVLTFLLLCYNAALTYMPSVSLQSLCQICSRICVCGYPRQHVRKYKGISSRIPVSSGFMVQMLTGIYFAFYNGEWDLAQKALDDIIYRAQLELYPEPLLVANAIKASLPHGPMKSNKEGTRCIQVEITPTSSRISRNAVTSMSIRGHRWKRHGNTELTGQEELMEISEVDEGFYSRAASSTSQSGLSNSSHNCSNKPSIGKNHRRSGGSKTGGKEKETTGESCKDHFARKQTQRAQSENLELLSLKRLTLTTSQSLPKPSSHGLAKTAATVFSKSFEQVSGVTVPHNPSSAVGCGAGTDANRFSACSLQEEKLIYVSERTELPMKHQSGQQRPPSISITLSTD
Organism_Source Homo sapiens
Functional_Classification Uncharacterized protein
Cellular_Localization Nucleus
Gene_Names HYCC1
UniProt_ID Q9BYI3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name WX-021
Peptide_Sequence LRXIQRXL
Peptide_Length 8
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)O
Chemical_Modification X3=(S)-2-(4'-pentenyl)alanine; X7=(S)-2-(4'-pentenyl)alanine
Cyclization_Method Main chain-main chain cyclization; X3<->X7; other bonds
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification ?-Ala-?-Ala-NH2
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 912.10
Aliphatic_Index 146.25000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 1.99798
Isoelectric_point 12.50011
Number_of_Hydrogen_Bond_Acceptors 12
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 433.91000
X_logP_energy -4.01496
Interaction Information
Affinity IC50=764 nM
Affinity_Assay GeneBLAzer? Wnt u-lactamase reporter assay
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Patent
Title STABILIZED BCL9 PEPTIDES FOR TREATMENT OF ABERRANT WNT SIGNALING
Release_Year 2021
Patent_ID US20210292385A1