PPIPT01975
Target Protein Information
| Protein_Name | Hyccin |
|---|---|
| Protein_Sequence | MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSELLEPVCHQLFEFYRSGEEQLLQFTLQFLPELIWCYLAVSASRNVHSSGCIEALLLGVYNLEIVDKQGHTKVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKVVYSGPHPQREMLTAQNRFEVLTFLLLCYNAALTYMPSVSLQSLCQICSRICVCGYPRQHVRKYKGISSRIPVSSGFMVQMLTGIYFAFYNGEWDLAQKALDDIIYRAQLELYPEPLLVANAIKASLPHGPMKSNKEGTRCIQVEITPTSSRISRNAVTSMSIRGHRWKRHGNTELTGQEELMEISEVDEGFYSRAASSTSQSGLSNSSHNCSNKPSIGKNHRRSGGSKTGGKEKETTGESCKDHFARKQTQRAQSENLELLSLKRLTLTTSQSLPKPSSHGLAKTAATVFSKSFEQVSGVTVPHNPSSAVGCGAGTDANRFSACSLQEEKLIYVSERTELPMKHQSGQQRPPSISITLSTD |
| Organism_Source | Homo sapiens |
| Functional_Classification | Uncharacterized protein |
| Cellular_Localization | Nucleus |
| Gene_Names | HYCC1 |
| UniProt_ID | Q9BYI3 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | WX-035 |
|---|---|
| Peptide_Sequence | XLQXLRXIQRXL |
| Peptide_Length | 12 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)O |
| Chemical_Modification | X1=(R)-2-(7'-octenyl)alanine; X7=(S)-2-(4'-pentenyl)alanine; X8=(S)-2-(4'-pentenyl)alanine; X11=(S)-2-(4'-pentenyl)alanine |
| Cyclization_Method | Multi-point cyclization; X1<->X8; other bonds; X7<->X11; other bonds |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | 2-Naphthylalanine-NH2 |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1267.50 |
|---|---|
| Aliphatic_Index | 130.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.75000 |
| Charge_at_pH_7 | 1.99798 |
| Isoelectric_point | 12.50011 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 17 |
| Number_of_Hydrogen_Bond_Donors | 21 |
| Topological_Polar_Surface_Area | 593.40000 |
| X_logP_energy | -6.50136 |
Interaction Information
| Affinity | IC50=1.858 uM |
|---|---|
| Affinity_Assay | CellTiter-Glo luminescent cell viability assay |
| PDB_ID | None |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | STABILIZED BCL9 PEPTIDES FOR TREATMENT OF ABERRANT WNT SIGNALING |
| Release_Year | 2021 |
| Patent_ID | US20210292385A1 |