PPIPT01981

Target Protein Information
Protein_Name Epithelial cell adhesion molecule
Protein_Sequence MAPPQVLAFGLLLAAATATFAAAQEECVCENYKLAVNCFVNNNRQCQCTSVGAQNTVICSKLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDESGLFKAKQCNGTSMCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSKSLRTALQKEITTRYQLDPKFITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKGESLFHSKKMDLTVNGEQLDLDPGQTLIYYVDEKAPEFSMQGLKAGVIAVIVVVVIAVVAGIVVLVISRKKRMAKYEKAEIKEMGEMHRELNA
Organism_Source Homo sapiens
Functional_Classification Ig-superfamily adhesion molecule
Cellular_Localization Plasma membrane
Gene_Names EPCAM
UniProt_ID P16422
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Ep114
Peptide_Sequence KHLQCVRNICWS
Peptide_Length 12
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C5<->C10; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1486.77
Aliphatic_Index 89.16667
Aromaticity 0.08333
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 1.96465
Isoelectric_point 8.83115
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 622.22000
X_logP_energy -5.44583
Interaction Information
Affinity KD=1.6 nM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title PEPTIDES THAT BIND TO EPITHELLAL CELL ADHESION MOLECULE
Release_Year 2015
Patent_ID US20150246945A1