PPIPT02006
Target Protein Information
| Protein_Name | Vasodilator-stimulated phosphoprotein |
|---|---|
| Protein_Sequence | MSETVICSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQVVINCAIVRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEALEGGGPPPPPALPTWSVPNGPSPEEVEQQKRQQPGPSEHIERRVSNAGGPPAPPAGGPPPPPGPPPPPGPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPAAQGPGGGGAGAPGLAAAIAGAKLRKVSKQEEASGGPTAPKAESGRSGGGGLMEEMNAMLARRRKATQVGEKTPKDESANQEEPEARVPAQSESVRRPWEKNSTTLPRMKSSSSVTTSETQPCTPSSSDYSDLQRVKQELLEEVKKELQKVKEEIIEAFVQELRKRGSP |
| Organism_Source | Homo sapiens |
| Functional_Classification | Actin-binding signaling regulator |
| Cellular_Localization | Cytoplasm |
| Gene_Names | VASP |
| UniProt_ID | P50552 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Ac-2-Cl-F-p-x-OH |
|---|---|
| Peptide_Sequence | XXX |
| Peptide_Length | 3 |
| Peptide_SMILES | NCC(=O)NCC(=O)NCC(=O)O |
| Chemical_Modification | X1=2-chlorophenylalanine; X2=diproline mimetic 85; X3=PPII-mimetic amino acid 86 |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 189.17 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 1.66667 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 4 |
| Number_of_Hydrogen_Bond_Donors | 4 |
| Topological_Polar_Surface_Area | 121.52000 |
| X_logP_energy | -2.73790 |
Interaction Information
| Affinity | KD=3 uM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | STRUCTURAL, MIMETCS OF PROLINE-RCH PEPTIDES AND USE THEREOF |
| Release_Year | 2015 |
| Patent_ID | US20150018269A1 |