PPIPT02016
Target Protein Information
| Protein_Name | Natural cytotoxicity triggering receptor 1 |
|---|---|
| Protein_Sequence | MSSTLPALLCVGLCLSQRISAQQQTLPKPFIWAEPHFMVPKEKQVTICCQGNYGAVEYQLHFEGSLFAVDRPKPPERINKVQFYIPDMNSRMAGQYSCIYRVGELWSEPSNLLDLVVTEMYDTPTLSVHPGPEVISGEKVTFYCRLDTATSMFLLLKEGRSSHVQRGYGKVQAEFPLGPVTTAHRGTYRCFGSYNNHAWSFPSEPVKLLVTGDIENTSLAPEDPTFPADTWGTYLLTTETGLQKDHALWDHTAQNLLRMGLAFLVLVALVWFLVEDWLSRKRTRERASRASTWEGRRRLNTQTL |
| Organism_Source | Homo sapiens |
| Functional_Classification | NK cell activating receptor (NCR1) |
| Cellular_Localization | Plasma membrane |
| Gene_Names | NCR1 |
| UniProt_ID | O76036 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | pep4 |
|---|---|
| Peptide_Sequence | TFYCRLDTATSMFLL |
| Peptide_Length | 15 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 1782.10 |
|---|---|
| Aliphatic_Index | 84.66667 |
| Aromaticity | 0.20000 |
| Average_Rotatable_Bonds | 3.66667 |
| Charge_at_pH_7 | -0.06440 |
| Isoelectric_point | 6.15812 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 25 |
| Number_of_Hydrogen_Bond_Donors | 26 |
| Topological_Polar_Surface_Area | 671.07000 |
| X_logP_energy | -4.66703 |
Interaction Information
| Affinity | KD=160 nM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | 1OLL |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | PEPTIDES DERIVED FROM THE ECTODOMAIN OF NKP46 |
| Release_Year | 2017 |
| Patent_ID | EP3211002A2 |