PPIPT02054

Target Protein Information
Protein_Name Tumor necrosis factor receptor superfamily member 16
Protein_Sequence MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSESTATSPV
Organism_Source Homo sapiens
Functional_Classification TNF receptor (death receptor family)
Cellular_Localization Plasma membrane
Gene_Names NGFR
UniProt_ID P08138
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name BDNF-C2
Peptide_Sequence WCTLTIKRGR
Peptide_Length 10
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1233.50
Aliphatic_Index 78.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 2.93571
Isoelectric_point 11.48119
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 531.29000
X_logP_energy -4.44396
Interaction Information
Affinity KD=35 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title NEUROTROPHIN-DERIVED PEPTIDE SEQUENCES
Release_Year 2009
Patent_ID US20090074779A1