PPIPT02058

Target Protein Information
Protein_Name Tumor necrosis factor receptor superfamily member 16
Protein_Sequence MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSESTATSPV
Organism_Source Homo sapiens
Functional_Classification TNF receptor (death receptor family)
Cellular_Localization Plasma membrane
Gene_Names NGFR
UniProt_ID P08138
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name BDNF-E
Peptide_Sequence RGIDKRHWNSQ
Peptide_Length 11
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1396.53
Aliphatic_Index 35.45455
Aromaticity 0.09091
Average_Rotatable_Bonds 4.27273
Charge_at_pH_7 2.08904
Isoelectric_point 11.47971
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 692.32000
X_logP_energy -8.12296
Interaction Information
Affinity KD=697 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title NEUROTROPHIN-DERIVED PEPTIDE SEQUENCES
Release_Year 2009
Patent_ID US20090074779A1