PPIPT02085

Target Protein Information
Protein_Name N-formyl peptide receptor 2
Protein_Sequence METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names FPR2
UniProt_ID P25090
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 58
Peptide_Sequence TIPMFVPESTSKLQKFTSWFM
Peptide_Length 21
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2505.97
Aliphatic_Index 50.95238
Aromaticity 0.19048
Average_Rotatable_Bonds 3.71429
Charge_at_pH_7 0.99917
Isoelectric_point 9.53730
Number_of_Hydrogen_Bond_Acceptors 34
Number_of_Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 897.34000
X_logP_energy -5.67920
Interaction Information
Affinity IC50=0.189 uM
Affinity_Assay Competitive binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title BIOACTIVE PEPTIDES AND METHOD OF USING SAME
Release_Year 2011
Patent_ID US20110104217A1