PPIPT02092

Target Protein Information
Protein_Name Synaptotagmin-1
Protein_Sequence MVSESHHEALAAPPVTTVATVLPSNATEPASPGEGKEDAFSKLKEKFMNELHKIPLPPWALIAIAIVAVLLVLTCCFCICKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKTMKDQALKDDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAMLAVKK
Organism_Source Homo sapiens
Functional_Classification Calcium sensor / vesicle trafficking protein
Cellular_Localization Extracellular
Gene_Names SYT1
UniProt_ID P21579
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name C2BL3C-NBD
Peptide_Sequence GGXDYDKIGKNDAX
Peptide_Length 14
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)CNC(=O)CN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NCC(=O)O
Chemical_Modification X3=L-propargylglycine; X14=e-azidonorleucine
Cyclization_Method Side chain-side chain cyclization; X3<->X14; other bonds
Linear/Cyclic Linear
N-terminal_Modification NBD-X
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1366.41
Aliphatic_Index 35.00000
Aromaticity 0.07143
Average_Rotatable_Bonds 3.35714
Charge_at_pH_7 -1.00212
Isoelectric_point 4.31197
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 668.88000
X_logP_energy -9.57050
Interaction Information
Affinity KD=0.51 mM
Affinity_Assay Fluorescence Polarization
PDB_ID 1UOW
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title COMPOSITIONS, METHODS AND USES FOR PEPTIDES IN DIAGNOSIS, PROGRESSION AND TREATMENT OF CANCERS
Release_Year 2015
Patent_ID US20150093333A1