PPIPT02112
Target Protein Information
| Protein_Name | Mitotic spindle assembly checkpoint protein MAD2A |
|---|---|
| Protein_Sequence | MALQLSREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKDDSAPREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPVND |
| Organism_Source | Homo sapiens |
| Functional_Classification | Cell cycle checkpoint protein (Mad2) |
| Cellular_Localization | Nucleus |
| Gene_Names | MAD2L1 |
| UniProt_ID | Q13257 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Cdc20P1 |
|---|---|
| Peptide_Sequence | DSKGGRILCYQNKAP |
| Peptide_Length | 15 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1649.89 |
|---|---|
| Aliphatic_Index | 58.66667 |
| Aromaticity | 0.06667 |
| Average_Rotatable_Bonds | 3.66667 |
| Charge_at_pH_7 | 1.93501 |
| Isoelectric_point | 9.40497 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 25 |
| Number_of_Hydrogen_Bond_Donors | 26 |
| Topological_Polar_Surface_Area | 739.81000 |
| X_logP_energy | -8.92613 |
Interaction Information
| Affinity | KD=3.6 uM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | CLASS OF 12MER PEPTIDES THAT INHIBIT THE FUNCTION OF THE MITOTIC CHECK POINT PROTEIN MAD2 |
| Release_Year | 2003 |
| Patent_ID | US20030083261A1 |