PPIPT02115

Target Protein Information
Protein_Name IgG receptor FcRn large subunit p51
Protein_Sequence MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
Organism_Source Homo sapiens
Functional_Classification Neonatal IgG transporter (FcRn)
Cellular_Localization Plasma membrane
Gene_Names FCGRT
UniProt_ID P55899
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 2G01D
Peptide_Sequence XXFXLYNNXGDPLXLC
Peptide_Length 16
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification X1=N-acetyl-3-nitro-D-tyrosine; X2=3-nitro-L-tyrosine; X4=3-nitro-L-tyrosine; X9=N锠-nitro-L-arginine; X14=3-nitro-L-tyrosine
Cyclization_Method Main chain-side chain cyclization; X1<->C16; other bonds
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1553.71
Aliphatic_Index 73.12500
Aromaticity 0.12500
Average_Rotatable_Bonds 2.93750
Charge_at_pH_7 -1.06439
Isoelectric_point 3.74997
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 634.74000
X_logP_energy -7.55050
Interaction Information
Affinity KD=290 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title SCREENING METHOD FOR PEPTIDE BINDING TO TARGET MOLECULE IN PH-DEPENDENT MANNER
Release_Year 2015
Patent_ID US20150133630A1