PPIPT02133
Target Protein Information
| Protein_Name | Interleukin-13 |
|---|---|
| Protein_Sequence | MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGQFN |
| Organism_Source | Homo sapiens |
| Functional_Classification | Cytokine (IL-13) |
| Cellular_Localization | Extracellular |
| Gene_Names | IL13 |
| UniProt_ID | P35225 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | D-D1 peptide |
|---|---|
| Peptide_Sequence | gsetwktiitkn |
| Peptide_Length | 12 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)CN)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)O)[C@@H](C)O)[C@@H](C)CC |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1377.56 |
|---|---|
| Aliphatic_Index | 65.00000 |
| Aromaticity | 0.08333 |
| Average_Rotatable_Bonds | 3.83333 |
| Charge_at_pH_7 | 0.99917 |
| Isoelectric_point | 9.53730 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 21 |
| Number_of_Hydrogen_Bond_Donors | 22 |
| Topological_Polar_Surface_Area | 612.56000 |
| X_logP_energy | -6.68840 |
Interaction Information
| Affinity | KD=100 mM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | IL13RALPHA2 PEPTIDE AND ITS USES |
| Release_Year | 2019 |
| Patent_ID | EP3480212A1 |