PPIPT02146

Target Protein Information
Protein_Name Glucagon-like peptide 1 receptor
Protein_Sequence MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Extracellular
Gene_Names GLP1R
UniProt_ID P43220
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name EU-A1023
Peptide_Sequence HXIGTMeFTSD
Peptide_Length 11
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1194.28
Aliphatic_Index 35.45455
Aromaticity 0.09091
Average_Rotatable_Bonds 3.45455
Charge_at_pH_7 -1.90889
Isoelectric_point 4.18115
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 518.29000
X_logP_energy -6.38980
Interaction Information
Affinity EC50=0.005 nM
Affinity_Assay cAMP assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title PEPTIDE PHARMACEUTICALS FOR INSULIN RESISTANCE
Release_Year 2018
Patent_ID US20180194826A1