PPIPT02153

Target Protein Information
Protein_Name HLA class II histocompatibility antigen, DRB1 beta chain
Protein_Sequence MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYFYNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS
Organism_Source Homo sapiens
Functional_Classification MHC class II molecule
Cellular_Localization Plasma membrane
Gene_Names HLA-DRB1
UniProt_ID P01911
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HNQVRQVPLQRLRIV
Peptide_Sequence HNQVRQVPLQRLRIV
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)C(C)C)C(=O)N[C@H](C(=O)O)C(C)C
Chemical_Modification lipidation
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification lipidation
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1856.21
Aliphatic_Index 136.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.13333
Charge_at_pH_7 3.08888
Isoelectric_point 12.80107
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 848.67000
X_logP_energy -7.77449
Interaction Information
Affinity IC50=1000 nM
Affinity_Assay radioligand binding assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title HLA-DR binding peptides and their uses
Release_Year 2016
Patent_ID EP3085707?A1