PPIPT02161

Target Protein Information
Protein_Name Tyrosine-protein phosphatase non-receptor type 1
Protein_Sequence MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
Organism_Source Homo sapiens
Functional_Classification Protein tyrosine phosphatase
Cellular_Localization Cytoplasm
Gene_Names PTPN1
UniProt_ID P18031
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name monocyclic-inhibitor-2
Peptide_Sequence SvPXHRRRRXFQ
Peptide_Length 12
Peptide_SMILES CC(C)[C@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)O
Chemical_Modification X=non-std;lowercase=D-amino
Cyclization_Method main chain-main chain cyclization; amide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1452.64
Aliphatic_Index 24.16667
Aromaticity 0.08333
Average_Rotatable_Bonds 3.91667
Charge_at_pH_7 4.08888
Isoelectric_point 12.97715
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 714.23000
X_logP_energy -9.32452
Interaction Information
Affinity IC50=30 nM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title Cell penetrating peptides and methods of making and using thereof
Release_Year 2022
Patent_ID US20220177523A1