PPIPT02164

Target Protein Information
Protein_Name Golgi-associated PDZ and coiled-coil motif-containing protein
Protein_Sequence MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
Organism_Source Homo sapiens
Functional_Classification Scaffold/adaptor protein (PDZ domains)
Cellular_Localization Cytoplasm
Gene_Names GOPC
UniProt_ID Q9HD26
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CAL-PDZ-inhibitor-8
Peptide_Sequence aXXXXRAXFRRRRK
Peptide_Length 14
Peptide_SMILES C[C@H](N)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification X=non-std;lowercase=D-amino
Cyclization_Method multi-point cyclization
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1501.72
Aliphatic_Index 14.28571
Aromaticity 0.07143
Average_Rotatable_Bonds 3.78571
Charge_at_pH_7 5.99767
Isoelectric_point 13.10476
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 777.14000
X_logP_energy -11.41445
Interaction Information
Affinity KD=489 nM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title Cell penetrating peptides and methods of making and using thereof
Release_Year 2022
Patent_ID US20220177523A1