PPIPT02167

Target Protein Information
Protein_Name Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Protein_Sequence MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
Organism_Source Homo sapiens
Functional_Classification Peptidyl-prolyl isomerase
Cellular_Localization Cytoplasm
Gene_Names PIN1
UniProt_ID Q13526
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Pin1-inhibitor-7
Peptide_Sequence aXaXXXaXFRRRRXK
Peptide_Length 15
Peptide_SMILES C[C@H](N)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification X=non-std;lowercase=D-amino
Cyclization_Method multi-point cyclization
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1473.66
Aliphatic_Index 20.00000
Aromaticity 0.06667
Average_Rotatable_Bonds 3.40000
Charge_at_pH_7 4.99768
Isoelectric_point 12.98095
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 744.34000
X_logP_energy -11.54162
Interaction Information
Affinity Ki=72 nM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title Cell penetrating peptides and methods of making and using thereof
Release_Year 2022
Patent_ID US20220177523A1