PPIPT02193
Target Protein Information
| Protein_Name | Terminal protein LMP2A |
|---|---|
| Protein_Sequence | MGSLEMVPMGAGPPSPGGDPDGDDGGNNSQYPSASGSSGNTPTPPNDEERESNEEPPPPYEDPYWGNGDRHSDYQPLGTQDQSLYLGLQHDGNDGLPPPPYSPRDDSSQHIYEEAGRGSMNPVCLPVIVAPYLFWLAAIAASCFTASVSTVVSATGLALSLLLLAAVANSSAAAQRKLLTPVTVLTAVVTFFAICLTWRIEDPPFNSILFALLAAAGGLQGIYVLVMLVLLILAYRRRWRRLTVCGGMMFLACLVVLIVDAVLQLSPLLGAVTVVSMTLLLLAFVLWLSSPGGLGTLGAALLTLAAALALLASLILGTLNLTTMFLLMLLWTLVVLLICSSCSSCPLSKVLLARLFLYALALLLLASALTAGGSILQTNFKSLSSSEFIPHLFCMLLLIVAAILFILAILTEWGSGNRTYGPVFMSLGGLLTMVAGAVWLTVMTNTLLSAWILTAGFLIFLIGFALFGVIRCCRYCCYYCLTLESEERPPTPYRNTV |
| Organism_Source | Epstein-Barr virus (strain GD1) |
| Functional_Classification | Terminal protein LMP2A |
| Cellular_Localization | Plasma membrane |
| Gene_Names | LMP2A |
| UniProt_ID | A0A191T791 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | EBV-LMP2 |
|---|---|
| Peptide_Sequence | CLGGLLTMV |
| Peptide_Length | 9 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CS)[C@@H](C)O)C(=O)N[C@H](C(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 906.17 |
|---|---|
| Aliphatic_Index | 162.22222 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.22222 |
| Charge_at_pH_7 | -0.06399 |
| Isoelectric_point | 5.92254 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 13 |
| Number_of_Hydrogen_Bond_Donors | 12 |
| Topological_Polar_Surface_Area | 316.35000 |
| X_logP_energy | -1.60250 |
Interaction Information
| Affinity | KD=2 nM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | 3REW |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | T CELL RECEPTOR LIKE ANTIBODY AGENTS SPECIFIC FOR EBV LATENT MEMBRANE PROTEIN 2A PEPTIDE PRESENTED BY HUMAN HLA |
| Release_Year | 2020 |
| Patent_ID | US20200115470A1 |