PPIPT02225

Target Protein Information
Protein_Name D(2) dopamine receptor
Protein_Sequence MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names DRD2
UniProt_ID P14416
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name B1_DR
Peptide_Sequence AGTAGATCACTG
Peptide_Length 12
Peptide_SMILES C[C@H](N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification X2=(+)-PPHT;X6=(+)-PPHT
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 983.08
Aliphatic_Index 33.33333
Aromaticity 0.00000
Average_Rotatable_Bonds 2.33333
Charge_at_pH_7 -0.12597
Isoelectric_point 5.82601
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 444.11000
X_logP_energy -9.29310
Interaction Information
Affinity EC50=22.3 nM
Affinity_Assay B-arrestin recruitment assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title CGAP-PNA MULTIVALENT PEPTOE NUCLEC ACID LGAND DISPLAY
Release_Year 2017
Patent_ID US20170002355A1