PPIPT02252

Target Protein Information
Protein_Name T-cell surface glycoprotein CD4
Protein_Sequence MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI
Organism_Source Homo sapiens
Functional_Classification Ig superfamily co-receptor
Cellular_Localization Plasma membrane
Gene_Names CD4
UniProt_ID P01730
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name peptide T
Peptide_Sequence ASTTTNYT
Peptide_Length 8
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 857.87
Aliphatic_Index 12.50000
Aromaticity 0.12500
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 -0.00287
Isoelectric_point 6.09320
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 431.49000
X_logP_energy -7.84900
Interaction Information
Affinity IC50=0.1 nM
Affinity_Assay radioligand binding assay
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Patent
Title Small peptides which inhibit binding to T-4 receptors and act as immunogens
Release_Year 1987
Patent_ID EP0249394A2