PPIPT02273

Target Protein Information
Protein_Name Capsid protein
Protein_Sequence MDVNASRALANVYDLPDDFFPQIDDLVRDAKDALEPYWKAETIKKHVLIATHFVDLIEDFWQTTQGMSQIADALRAVIPPTTVPVPEGFLITHSEAEEIPLNDLFSNQEERIVNFQPDYPITARIHTHLRVYTKLNEQALDKARRLLWWHYNCLLWGEATVTNYISRLRTWLSTPEKYRGKDAPTIEAITRPIQVAQGGRNQTKGTRKPRGLEPRRRKVKTTVVYGRRRSKSRGRRSSPSQRAGSPLPRNRGNQTRSPSPRE
Organism_Source Virus
Functional_Classification Viral capsid structural protein
Cellular_Localization Extracellular
Gene_Names C
UniProt_ID P0C6K0
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ADGALLGRMKPA
Peptide_Sequence ADGALLGRMKPA
Peptide_Length 12
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1199.43
Aliphatic_Index 90.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.25000
Charge_at_pH_7 0.99813
Isoelectric_point 9.69502
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 499.85000
X_logP_energy -4.72793
Interaction Information
Affinity KD=767 nM
Affinity_Assay solution-phase binding assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title HBV core antigen particles with multiple immunogenic components attached via peptide ligands
Release_Year 2004
Patent_ID US20040234554A1