PPIPT02294
Target Protein Information
| Protein_Name | Capsid protein |
|---|---|
| Protein_Sequence | MDVNASRALANVYDLPDDFFPQIDDLVRDAKDALEPYWKAETIKKHVLIATHFVDLIEDFWQTTQGMSQIADALRAVIPPTTVPVPEGFLITHSEAEEIPLNDLFSNQEERIVNFQPDYPITARIHTHLRVYTKLNEQALDKARRLLWWHYNCLLWGEATVTNYISRLRTWLSTPEKYRGKDAPTIEAITRPIQVAQGGRNQTKGTRKPRGLEPRRRKVKTTVVYGRRRSKSRGRRSSPSQRAGSPLPRNRGNQTRSPSPRE |
| Organism_Source | Virus |
| Functional_Classification | Viral capsid structural protein |
| Cellular_Localization | Extracellular |
| Gene_Names | C |
| UniProt_ID | P0C6K0 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | SLLGRMKG(B-A)C |
|---|---|
| Peptide_Sequence | SLLGRMKGBAC |
| Peptide_Length | 11 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | X9=beta-alanine; X10=Cys |
| Cyclization_Method | none |
| Linear/Cyclic | Linear |
| N-terminal_Modification | free |
| C-terminal_Modification | free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1092.34 |
|---|---|
| Aliphatic_Index | 80.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.45455 |
| Charge_at_pH_7 | 1.93571 |
| Isoelectric_point | 9.83324 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 17 |
| Number_of_Hydrogen_Bond_Donors | 18 |
| Topological_Polar_Surface_Area | 462.47000 |
| X_logP_energy | -5.67993 |
Interaction Information
| Affinity | IC50=1.8 uM |
|---|---|
| Affinity_Assay | solution-phase binding assay |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | HBV core antigen particles with multiple immunogenic components attached via peptide ligands |
| Release_Year | 2004 |
| Patent_ID | US20040234554A1 |