PPIPT02374

Target Protein Information
Protein_Name Interleukin-6
Protein_Sequence MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
Organism_Source Homo sapiens
Functional_Classification Cytokine (Interleukin family)
Cellular_Localization Extracellular
Gene_Names IL6
UniProt_ID P05231
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name UBITh1-EK-IL-662-83
Peptide_Sequence LNLPKMAEKDGCFQSGFNEETC
Peptide_Length 22
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification None
C-terminal_Modification None
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2461.76
Aliphatic_Index 40.00000
Aromaticity 0.09091
Average_Rotatable_Bonds 3.77273
Charge_at_pH_7 -2.12078
Isoelectric_point 4.14752
Number_of_Hydrogen_Bond_Acceptors 37
Number_of_Hydrogen_Bond_Donors 35
Topological_Polar_Surface_Area 1036.60000
X_logP_energy -11.72520
Interaction Information
Affinity IC50=1.08 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title Peptide immunogens targeting interleukin 6 (il-6) and formulations thereof for immunotherapy of diseases impacted by il-6 dysregulation
Release_Year 2022
Patent_ID US20220105163A1