PPIPT02397

Target Protein Information
Protein_Name Immunoglobulin heavy constant mu
Protein_Sequence SQSFPNVFPLVSCESPLSDKNLVAMGCLARDFLPSTISFTWNYQNNTEVIQGIRTFPTLRTGGKYLATSQVLLSPKSILEGSDEYLVCKIHYGGKNRDLHVPIPAVAEMNPNVNVFVPPRDGFSGPAPRKSKLICEATNFTPKPITVSWLKDGKLVESGFTTDPVTIENKGSTPQTYKVISTLTISEIDWLNLNVYTCRVDHRGLTFLKNVSSTCAASPSTDILTFTIPPSFADIFLSKSANLTCLVSNLATYETLNISWASQSGEPLETKIKIMESHPNGTFSAKGVASVCVEDWNNRKEFVCTVTHRDLPSPQKKFISKPNEVHKHPPAVYLLPPAREQLNLRESATVTCLVKGFSPADISVQWLQRGQLLPQEKYVTSAPMPEPGAPGFYFTHSILTVTEEEWNSGETYTCVVGHEALPHLVTERTVDKSTGKPTLYNVSLIMSDTGGTCY
Organism_Source Mus musculus
Functional_Classification Antibody constant region (IgM)
Cellular_Localization Extracellular
Gene_Names Ighm
UniProt_ID P01872
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide S
Peptide_Sequence ADGACRNPWC
Peptide_Length 10
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C5<-->C10; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1092.21
Aliphatic_Index 20.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 -0.12552
Isoelectric_point 6.06458
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 474.51000
X_logP_energy -5.86413
Interaction Information
Affinity IC50=200 uM
Affinity_Assay radioimmunoassay
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Patent
Title METHOD FOR THE OLIGOMERISATION OF PEPTIDES
Release_Year 2010
Patent_ID US20100105876A1