PPIPT02440

Target Protein Information
Protein_Name IgG receptor FcRn large subunit p51
Protein_Sequence MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
Organism_Source Homo sapiens
Functional_Classification IgG transport receptor (FcRn)
Cellular_Localization Plasma membrane
Gene_Names FCGRT
UniProt_ID P55899
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 2G01D
Peptide_Sequence dXFXLYNNXGDPLXLC
Peptide_Length 16
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification X1=N-acetyl-3-nitro-D-tyrosine; X3=3-nitro-L-tyrosine; X8=Nomega-nitro-L-arginine; X13=3-nitro-L-tyrosine
Cyclization_Method Main chain-side chain cyclization; X1<-->C15; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification N-chloroacetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1611.75
Aliphatic_Index 73.12500
Aromaticity 0.12500
Average_Rotatable_Bonds 3.06250
Charge_at_pH_7 -2.06395
Isoelectric_point 3.49187
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 672.04000
X_logP_energy -7.70720
Interaction Information
Affinity KD=290 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title SCREENING METHOD FOR PEPTIDE BINDING TO TARGET MOLECULE IN PH-DEPENDENT MANNER
Release_Year 2015
Patent_ID US20150133630A1