PPIPT02488
Target Protein Information
| Protein_Name | Catenin beta-1 |
|---|---|
| Protein_Sequence | MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL |
| Organism_Source | Homo sapiens |
| Functional_Classification | Transcriptional co-activator (Wnt signaling pathway) |
| Cellular_Localization | Cytoplasm |
| Gene_Names | CTNNB1 |
| UniProt_ID | P35222 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | WX-024 |
|---|---|
| Peptide_Sequence | LQTLXIQRXL |
| Peptide_Length | 10 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)O |
| Chemical_Modification | X5=(S)-2-(4'-pentenyl)alanine; X9=(S)-2-(4'-pentenyl)alanine |
| Cyclization_Method | Main chain-main chain cyclization; X5<-->X9; other bonds |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | acetyl |
| C-terminal_Modification | 2-Naphthylalanine-NH2 |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1098.31 |
|---|---|
| Aliphatic_Index | 156.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.80000 |
| Charge_at_pH_7 | 0.99798 |
| Isoelectric_point | 10.55000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 15 |
| Number_of_Hydrogen_Bond_Donors | 17 |
| Topological_Polar_Surface_Area | 493.53000 |
| X_logP_energy | -4.61623 |
Interaction Information
| Affinity | IC50=191 nM |
|---|---|
| Affinity_Assay | flourescence beta-lactamase reporter assay |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | STABILIZED BCL9 PEPTIDES FOR TREATMENT OF ABERRANT WNT SIGNALING |
| Release_Year | 2021 |
| Patent_ID | US20210292385A1 |