PPIPT02495

Target Protein Information
Protein_Name E-selectin
Protein_Sequence MIASQFLSALTLVLLIKESGAWSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLNSILSYSPSYYWIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIPLVAGLSAAGLSLLTLAPFLLWLRKCLRKAKKFVPASSCQSLESDGSYQKPSYIL
Organism_Source Homo sapiens
Functional_Classification Selectin cell adhesion receptor
Cellular_Localization Plasma membrane
Gene_Names SELE
UniProt_ID P16581
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name multivalent IELLOAR
Peptide_Sequence IELLOAR
Peptide_Length 7
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 770.93
Aliphatic_Index 181.42857
Aromaticity 0.00000
Average_Rotatable_Bonds 3.71429
Charge_at_pH_7 -0.00024
Isoelectric_point 6.41015
Number_of_Hydrogen_Bond_Acceptors 10
Number_of_Hydrogen_Bond_Donors 12
Topological_Polar_Surface_Area 337.12000
X_logP_energy -1.77523
Interaction Information
Affinity IC50=1 nM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title METHODS FOR INHIBITING TUMOR METASTASIS, AND PEPTIDES USEFUL THEREFOR
Release_Year 2003
Patent_ID US20030017170A1