PPIPT02501

Target Protein Information
Protein_Name Insulin-like growth factor-binding protein-like 1
Protein_Sequence MPRLSLLLPLLLLLLLPLLPPLSPSLGIRDVGGRRPKCGPCRPEGCPAPAPCPAPGISALDECGCCARCLGAEGASCGGRAGGRCGPGLVCASQAAGAAPEGTGLCVCAQRGTVCGSDGRSYPSVCALRLRARHTPRAHPGHLHKARDGPCEFAPVVVVPPRSVHNVTGAQVGLSCEVRAVPTPVITWRKVTKSPEGTQALEELPGDHVNIAVQVRGGPSDHEATAWILINPLRKEDEGVYQCHAANMVGEAESHSTVTVLDLSKYRSFHFPAPDDRM
Organism_Source Homo sapiens
Functional_Classification IGF-binding regulatory protein
Cellular_Localization Extracellular
Gene_Names IGFBPL1
UniProt_ID Q8WX77
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name LLLPLLPPLSPS
Peptide_Sequence LLLPLLPPLSPS
Peptide_Length 12
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method none
Linear/Cyclic Linear
N-terminal_Modification free
C-terminal_Modification free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1259.59
Aliphatic_Index 195.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 2.75000
Charge_at_pH_7 -0.00202
Isoelectric_point 6.10000
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 11
Topological_Polar_Surface_Area 388.72000
X_logP_energy 0.01710
Interaction Information
Affinity KD=1 uM
Affinity_Assay ELISA
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title Novel peptides, combination of peptides as targets and for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers
Release_Year 2021
Patent_ID US20210380662A1